Pd(II)-β-cyclodextrin complex: Synthesis, characterization and efficient nanocatalyst for the selective Suzuki-Miyaura coupling reaction in water

• Preparation of novel water soluble Pd(II)-β-cyclodextrin complex without any ligand.
• Suzuki-Miyaura catalytic coupling reaction.
• The catalytic behavior of the Pd(II)-β-cyclodextrin complex in coupling reaction.
• Reusability of Pd(II)-β-cyclodextrin homogeneous catalyst in Suzuki-Miyaura coupling reactions.

Herein we report the preparation, characterization and the catalytic ability of novel Pd(II)-β-cyclodextrin complex as an efficient nanocatalytic system for the Suzuki–Miyaura carbon-carbon (CC) coupling reaction in water. The presented novel Pd(II)-β-cyclodextrin complex catalyst was characterized by TGA, FT-IR, XRD, NMR and atomic absorption analysis. Also, by using the Pd(II)-β-CD complex as a homogeneous catalyst, we have developed an efficient protocol for suzuki-Miyaura coupling reaction of aryl boronic acids with aryl halides in neat water with high turnover frequencies (TOFs) for the synthesis of unsymmetrical biaryls. The catalyst can be recycled and reused multiple times to catalyze the coupling reaction.

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