کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1322064 1499917 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Platinum(II) and gold(I) complexes based on 1,1′-bis(diphenylphosphino)metallocene derivatives: Synthesis, characterization and biological activity of the gold complexes
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Platinum(II) and gold(I) complexes based on 1,1′-bis(diphenylphosphino)metallocene derivatives: Synthesis, characterization and biological activity of the gold complexes
چکیده انگلیسی

The synthesis of series of 1,2,1′ substituted bis(diphenylphosphino)- ruthenocenyl (1–4) and ferrocenyl cis-platinum(II) (5–7) and gold(I) (8–12) complexes are described. Crystal structures of 2 and 4, as well as 5, 6 and 10 confirm the molecular geometry of these ligands and their metal complexes. Preliminary investigation of four gold complexes as potential anticancer, antiHIV and antimalaria showed at least one gold compound that has excellent activity towards one of these diseases. The three gold(I) complexes, {1- [1-(dimethylamino)ethyl]-1 ,2-bis(diphenylphosphino)ruthenocene-κ2P,P′}bis[chlorogold(I)] (8) (IC50 = 1.40 μM), {1-[1-(acetoxyethyl)-1′,2-bis(diphenylphosphino)ferrocene-κ2P,P′]bis[chlorogold(I)] (9) (IC50 = 0.51 μM), {1-[1-(3-carboxypropanamido)ethyl]-1′,2-bis(diphenylphosphino)-ruthenoceneκ2P,P′}bis[chlorogold(I)] (12) (IC50 = 1.784 μM), have the best activities against cancer, HIV and malaria respectively.

Platinum(II) and gold(I) (diphenylphosphino) ferrocene and ruthenocene complexes have been prepared. These gold(I) complexes show remarkable activity towards HeLa cells, type 1 HIV and Plasmodium falciparum.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Organometallic Chemistry - Volume 720, 1 December 2012, Pages 52–59
نویسندگان
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