Palladium catalyzed direct C-2 arylation of indoles

• A new NCN Pincer–palladium complexes was synthesized and characterized.
• The catalyst showed efficient activity for arylation of N-substituted indoles.
• The catalyst enabled the synthesis of 2-arylindoles with excellent selectivities.

The synthesis and catalytic evaluation of palladium complexes containing NCN Pincer ligand is reported. The pincer palladium complexes as (pre)catalyst showed efficient catalytic activity for the C–H arylation of N-substituted indoles, allowing the synthesis of 2-arylindoles with moderate to good yields and excellent regioselectivities.

The synthesis and catalytic evaluation of palladium complexes containing NCN Pincer ligand is reported. The pincer palladium complexes as (pre)catalyst showed efficient catalytic activity for the C–H arylation of N-substituted indoles, allowing the synthesis of 2-arylindoles with moderate to good yields and excellent regioselectivities.Figure optionsDownload as PowerPoint slide