Demetallation of 1,3-diene products obtained from addition of natural products to tricarbonyl(cyclohexadienyl)iron tetrafluoroborate

• Some biologically active natural products were added to tricarbonyl (cyclohexadienyl) iron to give adducts.
• The adducts formed were demetallated using the oxidizing agent trimethylamine-N-oxide to give new organic compounds.
• The adducts and the new compounds were characterized using IR, MS, NMR (1H, 13C).

The demetallation of adducts obtained from the addition of biologically active natural products to [Fe (1-5-η-C6H7) (CO)3][BF4] using the oxidizing agent, trimethylamine-N-oxide, afford new organic compounds which are otherwise inaccessible by conventional organic techniques. The products of demetallation were characterized using NMR (1H, 13C), MS and IR spectroscopic measurements.

We report the addition of the biologically active natural products, gedunin, khivorin, polyavolensinol and 7-ketokhivorin to the complex [Fe(CO)3(1-5-η-C6H7)][BF4] to afford neutral substituted 1,3-diene products which on demetallation using the oxidizing agent, Me3NO afforded novel organic compounds of potential medicinal value.Figure optionsDownload as PowerPoint slide