کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1322633 1499898 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Syntheses, structural characterization and in vitro cytotoxic activity of triorganotin(IV) complexes based on 1,7-dihydroxycarbonyl-1,7-dicarba-closo-dodecaborane ligand
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Syntheses, structural characterization and in vitro cytotoxic activity of triorganotin(IV) complexes based on 1,7-dihydroxycarbonyl-1,7-dicarba-closo-dodecaborane ligand
چکیده انگلیسی


• Seven novel carborane-based triorganotin compounds were synthesized.
• There exists two kinds of complexes, the binuclear monomer and the polymers.
• Most of the complexes show higher cytotoxic activities against cancer cell lines.

Seven novel triorganotin(IV) compounds containing m-CDC2− (m-CDCH2 = 1,7-dihydroxycarbonyl-1,7-dicarba-closo-dodecaborane) have been synthesized and structural characterized. The central tin atoms are five-coordinated to assume a distorted trigonal bipyramidal configuration not only in the binuclear monomers 1, 3 and 4 but also in the polymers 2, 5, 6 and 7. It was observed that complexes 3, 4 and 5 could be obtained only in the presence of the ancillary carboxylate ligands, 2,3-pyrazinedicarboxylic acid, 2-pyridinecarboxylic acid and 2,6-pyridinedicarboxylic acid, respectively. The reaction of m-CDCH2 with (n-Bu3Sn)2O in the presence of the bridging ligands 4,4′-bipyridine and 4,4′-vinylenedipyridine afforded one-dimensional coordination polymers 6 and 7, respectively. Most of the complexes exhibit higher cytotoxic activities than cis-platin against two cancer cell lines, K-562 and Hela.

Seven novel triorganotin compounds with 1,7-dihydroxycarbonyl-1,7-dicarba-closo-dodecaborane as the ligand were synthesized and characterized. Most of the complexes exhibit higher cytotoxic activities against two cancer cell lines, K-562 and Hela.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Organometallic Chemistry - Volume 740, 15 September 2013, Pages 1–9
نویسندگان
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