کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1322818 1499908 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Arene ruthenium dichloro complexes containing isonicotinic ester ligands: Synthesis, molecular structure and cytotoxicity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Arene ruthenium dichloro complexes containing isonicotinic ester ligands: Synthesis, molecular structure and cytotoxicity
چکیده انگلیسی

A series of p-cymene ruthenium dichloro complexes containing isonicotinic ester ligands, [(arene)RuCl2NC5H4-4-COO–C6H4–p-O-(CH2)n-CH3] (n = 1: 1, n = 3: 2, n = 5: 3, n = 7: 4, n = 9: 5, n = 11: 6, n = 13: 7, n = 15: 8), were prepared from p-cymene ruthenium dichloro dimer and the corresponding isonicotinic ester ligand. The single-crystal X-ray analysis of 1 shows the molecule to adopt the usual pseudo-tetrahedral piano-stool geometry, the isonicotinic ester ligand being coordinated through the nitrogen atom. The cytotoxicity of all complexes and of the free ligands was studied towards human ovarian cancer cells; high activities were observed only for n = 9 (presenting a chain with ten carbon atoms), both as far as the free ligands and the complexes are concerned. Based on this result, a new isonicotinic ester ligand with a C10 substituent containing a terminal alcohol function, NC5H4-4-COO–C6H4–p-O–(CH2)10–OH, was synthesized by a four-step method, and arene ruthenium complexes thereof, [(arene)RuCl2NC5H4-4-COO–C6H4–p-O–(CH2)10–OH] (arene = C6H6: 9a, arene = p-MeC6H4Pri: 9b, arene = C6Me6: 9c) were prepared. The complexes 9a and 9b show indeed remarkable anticancer activities, the IC50 values for human ovarian cancer cells being in the submicromolar range. The highest cytotoxicity was observed for complex 9b, with IC50 values of 0.18 μM for A2780 and 3.04 μM for the cisplatin-resistant mutant A2780cisR.

The heterodinuclear complexes [((6-p-MeC6H4Pri)RuCl2(Ph2PfcCONHRCO2Me-(P)] have been synthesized from p-cymene ruthenium dichloride dimer and phosphinoferrocene ligands bearing carboxamide substituents derived from amino acids and studied for their in vitro anticancer activity towards human ovarian cancer cell lines.Figure optionsDownload as PowerPoint slideHighlights
► Arene ruthenium complexes containing isonicotinic ester ligands have been synthesized.
► The X-ray analysis confirms a pseudo-tetrahedral piano-stool geometry.
► These complexes are highly cytotoxic, in particular with a C10 chain substituent.
► The cytotoxicity was further enhanced by introducing a terminal hydroxyl group.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Organometallic Chemistry - Volume 730, 15 April 2013, Pages 49–56
نویسندگان
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