کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1322860 977252 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Proliferative and anti-proliferative effects of titanium- and iron-based metallocene anti-cancer drugs
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Proliferative and anti-proliferative effects of titanium- and iron-based metallocene anti-cancer drugs
چکیده انگلیسی

In previous work we have found that Cp2TiCl2 and its corresponding derivative of tamoxifen, Titanocene tamoxifen, show an unexpected proliferative effect on hormone dependent breast cancer cells MCF-7. In order to check if this behavior is a general trend for titanocene derivatives we have tested two other titanocene derivatives, Titanocene Y and Titanocene K, on this cell line. Interestingly, these two titanocene complexes behave in a totally different manner. Titanocene K is highly proliferative on MCF-7 cells even at low concentrations (0.5 μM), thus behave almost similarly to Cp2TiCl2. This proliferative effect is also observed in the presence of bovine serum albumin (BSA). In contrast, Titanocene Y alone has almost no effect on MCF-7 at a concentration of 10 μM, but exhibits a significant dose dependent cytotoxic effect of up to 50% when incubated with BSA (20–50 μg/mL). This confirms the crucial role played by the binding to serum proteins in the expression of the in vivo, cytotoxicity of the titanocene complexes. From the hydridolithiation reaction of 6-p-anisylfulvene with LiBEt3H followed by transmetallation with iron dichloride [bis-[(p-methoxy-benzyl)cyclopentadienyl]iron(II)] (Ferrocene Y) was synthesised. This complex, which was characterised by single crystal X-ray diffraction, contains the robust ferrocenyl unit instead of Ti associated with easily leaving groups such as chlorine and shows only a modest cytotoxicity against MCF-7 or MDA-MB-231 cells.

On hormone dependent breast cancer cells, Titanocene K is highly proliferative at low concentration (0.5 μM) while Titanocene Y has almost no effect at 10 μM but exhibits a significant dose dependent cytotoxic effect when incubated with serum albumin. Ferrocene Y shows only a modest anti-proliferative effect on these cells.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Organometallic Chemistry - Volume 694, Issue 6, 15 March 2009, Pages 874–879
نویسندگان
, , , , , , , , ,