کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1322865 | 977252 | 2009 | 8 صفحه PDF | دانلود رایگان |
Dialkyl- and diphenyl phosphites react with the (η5-C5H5)M(CO)x(η1-N-maleimidato) (M = Fe, Mo; x = 2 or 3) complexes giving products of the phospha-Michael addition to the η1-N-maleimidato ligand. One of these complexes (M = Fe, x = 2) was characterized by X-ray diffraction. The synthesized metallocarbonyl azaphosphonates and the corresponding iron phosphonic acid act as inhibitors of certain serine hydrolases (AChE and BChE). The kinetic assays were performed and revealed that inhibition mechanism depends strongly on the enzyme and the structure of the inhibitor.
Dialkyl- and diphenyl phosphites react with the (η5-C5H5)M(CO)x(η1-N-maleimidato) (M = Fe, Mo; x = 2 or 3) complexes giving products of the phospha-Michael addition to the η1-N-maleimidato ligand. The synthesized metallocarbonyl azaphosphonates and the corresponding iron phosphonic acid act as inhibitors of certain serine hydrolases (AChE and BChE). The inhibition mechanism depends strongly on the enzyme and the structure of the inhibitor.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 694, Issue 6, 15 March 2009, Pages 908–915