Development and efficient 1-glycyl-3-methyl imidazolium chloride–copper(II) complex catalyzed highly enantioselective synthesis of 3, 4-dihydropyrimidin-2(1H)-ones

A novel, effective asymmetric 1-glycyl-3-methyl imidazolium chloride-copper(II) complex [[Gmim]Cl–Cu(II)] was synthesized and studied as organocatalyst for enantioselective Biginelli reaction under solvent free condition at 25°C. The hydrophobic group on amino acid favors reagent diffusion towards the chloroglycine moiety increasing the catalytic activity of supported palladium complex. Spectroscopic evidence of complex has been proved by Powder XRD, SEM, FT-IR and AFM. This method contains simplified product isolation and catalyst recycling, affording substituted aldehydes imparting high yield with excellent stereoselectivity. This recyclable heterogeneous catalyst provides a simple strategy for the generation of a variety of new C–C bonds under environmentally benign condition.

An efficient [Gmim] Cl–Cu (II) catalyst for enantioselective synthesis of 3, 4-dihydropyrimidin-2(1H)-ones in the absence of an organic co-solvent. The procedure is easy and does not require special precautions. The solid catalyst was simply isolated by separation or centrifugation and was recycled smoothly for several runs without appreciable loss of its catalytic activity.Figure optionsDownload as PowerPoint slideHighlights
► An efficient [Gmim] Cl–Cu (II) catalyst for enantioselective Biginelli reaction.
► The procedure is easy and does not require special precautions.
►  The catalyst was reused for several runs without loss of its catalytic activity.