کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1323313 | 1499929 | 2012 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis, characterization and antitumor activity of novel amide derivatives containing ferrocenyl pyrazol-moiety Synthesis, characterization and antitumor activity of novel amide derivatives containing ferrocenyl pyrazol-moiety](/preview/png/1323313.png)
A series of novel 2-(5-ferrocenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)-N-amide derivatives (1–38) were prepared. The compounds were characterized by 1H NMR, 13C NMR, IR, mass spectroscopy and element analysis. Compounds 19 and 30 were also gave crystals suitable for X-ray structural analysis. Biological evaluation of all the compounds were performed in the human prostatic carcinoma cell line (PC-3) and human mammary carcinoma cell line (Bcap-37) using the MTT method. Among them, compound 10 exhibited comparable in vitro antitumor activity to the positive control 5-Fluorouracil (5-FU) and cisplatin.
The antitumor activity of a series of novel 2-(5-ferrocenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)-N-amide derivatives (1–38) has been studied against two human tumor cell lines (PC-3 and Bcap-37). Compound 10 displayed the best cytotoxicity and can be pointed out as a promising substrate to be subject of further investigations.Figure optionsDownload as PowerPoint slideHighlights
► A series of novel ferrocene-containing amide derivatives were synthesized.
► Compounds 19 and 30 had been characterized by X-ray crystallography.
► Compound 10 exhibited comparable in vitro antitumor activity to the positive control adriamycin.
Journal: Journal of Organometallic Chemistry - Volumes 706–707, 1 June 2012, Pages 113–123