کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1323397 | 977285 | 2007 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: [18F]Fluorophenyl organometallics as intermediates of no-carrier-added 18F-fluoroarylation reactions [18F]Fluorophenyl organometallics as intermediates of no-carrier-added 18F-fluoroarylation reactions](/preview/png/1323397.png)
Based on the recent availability of no-carrier-added (n.c.a.) 1-bromo-4-[18F]fluorobenzene with high radiochemical yield, the 4-[18F]fluorophenyl compounds of lithium, sodium and magnesium can now also effectively be prepared. Thus, [18F]fluoroarene reagents with a nucleophilic reaction centre are available and suitable among others for the formation of [18F]fluorophenyl compounds with electron donating substituents in the radiosynthesis of 18F-labelled complex organic structures. For these arylation reactions, however, the presence of macroscopic amounts of a haloarene as co-reactant is necessary with all n.c.a. [18F]fluorophenyl metallics. The 18F-fluoroarylation was verified for examples of aryl-carbon, -silicon, -sulphur, and -nitrogen bond formation with radiochemical yields of 20–25% related to the starting radioactivity of [18F]fluoride.
Studies of the synthesis and synthetic potential of no-carrier-added 4-[18F]fluorophenyl compounds of lithium, sodium and magnesium. The 18F-fluoroarylation was verified with examples of aryl-carbon, -silicon, -sulphur, and -nitrogen bond formation with radiochemical yields of 20–25% related to the starting radioactivity of [18F]fluoride.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 692, Issue 19, 1 September 2007, Pages 4084–4092