Synthesis of 4-amino-2-trifluormethyl quinoline derivatives via palladium-catalyzed cascade reactions of isocyanides with N-(ortho-iodo)aryl enamines

• A novel approach to 4-amino-2-trifluormethylquinoline derivatives is described.
• Isocyanides as a C1 building blocks were used to construct heterocycles.
• The target heterocycles can be found in many natural products or drugs.

A novel efficient synthetic approach to 4-amino-2-trifluormethyl quinoline derivatives is described via palladium-catalyzed cascade reactions of isocyanides with readily available N-(ortho-iodo)aryl enamines under mild conditions. The target heterocycles can be found in many natural products or drugs, which were obtained in generally good to excellent yield.

A novel efficient synthetic approach to 4-amino-2-trifluormethyl quinoline derivatives is described via palladium-catalyzed cascade reactions of isocyanides with readily available N-(ortho-iodo)aryl enamines under mild conditions. The target heterocycles can be found in many natural products or drugs, which were obtained in generally good to excellent yield.Figure optionsDownload as PowerPoint slide