کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1323448 | 1499859 | 2015 | 6 صفحه PDF | دانلود رایگان |

• A novel approach to 4-amino-2-trifluormethylquinoline derivatives is described.
• Isocyanides as a C1 building blocks were used to construct heterocycles.
• The target heterocycles can be found in many natural products or drugs.
A novel efficient synthetic approach to 4-amino-2-trifluormethyl quinoline derivatives is described via palladium-catalyzed cascade reactions of isocyanides with readily available N-(ortho-iodo)aryl enamines under mild conditions. The target heterocycles can be found in many natural products or drugs, which were obtained in generally good to excellent yield.
A novel efficient synthetic approach to 4-amino-2-trifluormethyl quinoline derivatives is described via palladium-catalyzed cascade reactions of isocyanides with readily available N-(ortho-iodo)aryl enamines under mild conditions. The target heterocycles can be found in many natural products or drugs, which were obtained in generally good to excellent yield.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 783, 1 May 2015, Pages 77–82