کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1323703 | 977301 | 2011 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Ferrocenylthiosemicarbazones conjugated to a poly(propyleneimine) dendrimer scaffold: Synthesis and in vitro antimalarial activity Ferrocenylthiosemicarbazones conjugated to a poly(propyleneimine) dendrimer scaffold: Synthesis and in vitro antimalarial activity](/preview/png/1323703.png)
First-generation ferrocenylthiosemicarbazone metallodendrimers based on a poly(propyleneimine) dendrimer scaffold were synthesised with ferrocenylthiosemicarbazone moieties conjugated to the periphery of the branched polyamine scaffolds. The compounds were characterised by NMR and IR spectroscopy, elemental analysis and ESI-mass spectrometry. These new complexes were evaluated as bioorganometallic antimalarial agents against the Plasmodium falciparum chloroquine-resistant W2 strain. In vitro antiplasmodial assays of the dendritic ferrocenylthiosemicarbazones against the malaria parasite P. falciparum show increased efficacy compared to the precursor non-conjugated thioesters.
First-generation ferrocenylthiosemicarbazone complexes based on a poly(propylene imine) dendritic scaffold were synthesised. The in vitro antimalarial studies of the tetranuclear dendritic complexes were evaluated against the Plasmodium falciparum chloroquine-resistant W2 strain.Figure optionsDownload as PowerPoint slideHighlights
► Ferrocenylthiosemicarbazone dendrimers have been prepared.
► The metallodendrimers were evaluated as antimalarial drugs.
► The dendrimers show enhanced activity compared to non-conjugated thioesters.
Journal: Journal of Organometallic Chemistry - Volume 696, Issue 21, 15 October 2011, Pages 3296–3300