کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1323717 | 977301 | 2011 | 5 صفحه PDF | دانلود رایگان |
Highly functionalized tetrasubstituted allylic alcohols were prepared conveniently by CuI-catalyzed tandem carbomagnesiation/carbonyl addition of Grignard reagents with acetylenic ketones. The obtained allylic alcohols can be further transformed to polysubstituted indenes by intramolecular cyclization.
Highly functionalized tetrasubstituted allylic alcohols were prepared conveniently by CuI-catalyzed tandem carbomagnesiation/carbonyl addition of Grignard reagents with acetylenic ketones. The obtained allylic alcohols can be further transformed to polysubstituted indenes by intramolecular cyclization.Figure optionsDownload as PowerPoint slideHighlights
► One-pot tandem reaction of Grignard reagents and acetylenic ketones was studied.
► Highly functionalized tetrasubstituted allylic alcohols were synthesized.
► The obtained allylic alcohols can be further transformed to polysubstituted indenes.
Journal: Journal of Organometallic Chemistry - Volume 696, Issue 21, 15 October 2011, Pages 3397–3401