کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1324276 1499889 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Opening the lid on piano-stool complexes: An account of ruthenium(II)–arene complexes with medicinal applications
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Opening the lid on piano-stool complexes: An account of ruthenium(II)–arene complexes with medicinal applications
چکیده انگلیسی


• The origins of bioorganometallic (medicinal) chemistry.
• Properties of Ru(II)–arene complexes lend themselves pharmacological applications.
• Rational target specific drug design.
• Drug targeting strategies.
• Beyond the ruthenium(II)–arene unit: Os, Rh and Ir and cyclopentadienyl systems.

Interest in the medicinal properties of ruthenium(II)–arene compounds has grown rapidly over the last decade. In this account we describe the origins of the field and subsequently highlight developments in the field, including the design of compounds that inhibit enzymes, the application of multinuclear systems to act as drug delivery vehicles, and the development of bioanalytical and biophysical methods to help elucidate the mechanisms by which these compounds function. The conducive properties and reasons for the rapid growth in interest in these and related compounds for their medicinal applications, especially in the treatment of solid tumours, are identified.

The medicinal properties of ruthenium(II)–arene compounds are attracting growing interest but how long will it be for one of these compounds to enter clinical trials?Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Organometallic Chemistry - Volume 751, 1 February 2014, Pages 251–260
نویسندگان
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