Copper(I) trifluoromethylthiolate complex bearing triphenylphosphine ligand for nucleophilic trifluoromethylthiolation of allylic bromides

• Copper(I) trifluoromethylthiolate complex (PPh3)2Cu(SCF3) has been prepared and structurally characterized.
• (PPh3)2Cu(SCF3) was found to be effective in the trifluoromethylthiolation of allylic bromides.
• The reaction is compatible with several important functional groups.

Copper(I) trifluoromethylthiolate complex (PPh3)2Cu(SCF3) (1) has been synthesized from a convenient reaction of CuF2 with CF3SiMe3 and S8 in the presence of triphenylphosphine. The crystal structure of complex 1 has been determined by X-ray crystallography. In the solid state, complex 1 exists as a monomeric copper(I) species with a three-coordinated trigonal planar geometry. Complex 1 reacted with a wide range of allylic bromides to afford corresponding allylic trifluoromethyl thioethers in moderate to good yields. Several functional groups, including alkyl, alkoxy, nitro, halides and geranyl groups, are tolerated.

Copper(I) trifluoromethylthiolate complex (PPh3)2Cu(SCF3) (1) has been synthesized and characterized. In the solid state, complex 1 exists as a monomeric copper(I) species with a three-coordinated trigonal planar geometry. Complex 1 reacted with a wide range of allylic bromides to afford corresponding allylic trifluoromethyl thioethers in moderate to good yields.Figure optionsDownload as PowerPoint slide