Synthesis, characterization and antibacterial studies of ferrocenyl and cymantrenyl hydrazone compounds

Cymantrenyl Schiff base compounds [(CO)3Mn{(η5-C5H4)C(CH3)N–N(H)C(O)R}] (4–7) (R = C6H4–OH, C5H4N-p, C6H5, C5H4N-o) have been synthesized by room temperature reaction and their structural characterization was performed by single crystal X-ray diffraction studies. Room temperature reaction of mono- and di-acetyl ferrocene with salicyloyl and isonicotinyl hydrazides led to the formation of the some organometallic Schiff base compounds containing monosubstituted, disubstituted and unsymmetrically substituted ferrocenyl fragments, [(η5-C5H5)Fe{(η5-C5H4)C(CH3)N–N(H)C(O)–R}] (8, 9), [Fe{(η5-C5H4)C(CH3)NN(H)C(O)R}2] (10, 12) (R = C6H4–OH, C5H4N), [{(η5-C5H4)COCH3}Fe{(η5-C5H4)C(CH3)NN(H)C(O)(C5H4N)}] (11) and [Fe{(η5-C5H4)C(CH3)N–N(H)C(O)(C5H4N)}{(η5-C5H4)C(CH3)NN(H)C(O)C6H4–OH}] (13) respectively. Antibacterial studies and electrochemical analysis were carried out for some of the compounds. Molecular structure determination was performed for compounds 4, 5, 8 and 9 by single crystal X-ray diffraction technique.

Cymantrenyl and ferrocenyl Schiff base organometallic compounds have been synthesized by the reaction between respective acetylated organometallic fragments and hydrazide compounds. Compounds 4, 5, 8 and 9 have been structurally characterized by single crystal X-ray diffraction studies. Antibacterial studies and electrochemical analysis were performed for some of the ferrocenyl and cymantrenyl compounds.Figure optionsDownload as PowerPoint slideHighlights
► Synthesis and reactivity of ferrocenyl and cymantrenyl compounds.
► Electrochemical properties study of ferrocenyl Schiff base compounds.
►  Antimicrobial study with the synthesized organometallic compounds.