Iridium complexes inhibit tumor necrosis factor-α by utilizing light and mixed ligands

• 51 racemic iridium(III) complexes, both cationic and neutral, were synthesized.
• All of them were efficient inhibitors of TNF-α/TNF Receptor-1 interaction.
• Potent synergic effects were observed when mixing racemic iridium complexes.
• The inhibition was increased when using white light.

We report herein a large study of the inhibition of tumor necrosis factor-α with 51 iridium(III) complexes, thus highlighting the influence of the nature of the ligands around the metal, their synergic effect and the role of the light.

Iridium(III) complexes inhibit TNF-α/TNF-Receptor 1 interaction.Figure optionsDownload as PowerPoint slide