کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1324950 977361 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation and biological evaluation of 99mTc-CO-MIBI as myocardial perfusion imaging agent
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Preparation and biological evaluation of 99mTc-CO-MIBI as myocardial perfusion imaging agent
چکیده انگلیسی

99mTc-Sestamibi has been playing an important role in the cardiac imaging for the last decades. Previously, we reported that [99mTc(CO)3(MIBI)3]+ demonstrated a significant location in myocardium with a lower liver uptake as compared with 99mTc-Sestamibi. In this work, we found that new [99mTc(CO)2(MIBI)4]+ could be prepared with high radiochemical purity. The inter-transformations between [99mTc(CO)3(H2O)(MIBI)2]+, [99mTc(CO)3(MIBI)3]+, and [99mTc(CO)2(MIBI)4]+ were investigated and biodistribution was performed to evaluate the [99mTc(CO)2(MIBI)4]+ as a myocardial perfusion imaging agent. The results showed that one more CO was replaced by MIBI slowing down the pharmacokinetics. The structure characterization was performed on their corresponding rhenium complexes, and the results indicated that there were differences between 99mTc-CO-MIBI and Re-CO-MIBI in preparation and hydrophobic characteristics.

The inter-transformations between [99mTc(CO)3(H2O)(MIBI)2]+, [99mTc(CO)3(MIBI)3]+, and [99mTc(CO)2(MIBI)4]+ were investigated. The biodistribution results showed that [99mTc(CO)3(MIBI)3]+ had the most favorable characteristics for cardiac imaging. The structure characterization on their corresponding rhenium complexes indicated that there were differences between 99mTc-CO-MIBI and Re-CO-MIBI in preparation and hydrophobic characteristics.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Organometallic Chemistry - Volume 693, Issue 10, 1 May 2008, Pages 1822–1828
نویسندگان
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