کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1324950 | 977361 | 2008 | 7 صفحه PDF | دانلود رایگان |

99mTc-Sestamibi has been playing an important role in the cardiac imaging for the last decades. Previously, we reported that [99mTc(CO)3(MIBI)3]+ demonstrated a significant location in myocardium with a lower liver uptake as compared with 99mTc-Sestamibi. In this work, we found that new [99mTc(CO)2(MIBI)4]+ could be prepared with high radiochemical purity. The inter-transformations between [99mTc(CO)3(H2O)(MIBI)2]+, [99mTc(CO)3(MIBI)3]+, and [99mTc(CO)2(MIBI)4]+ were investigated and biodistribution was performed to evaluate the [99mTc(CO)2(MIBI)4]+ as a myocardial perfusion imaging agent. The results showed that one more CO was replaced by MIBI slowing down the pharmacokinetics. The structure characterization was performed on their corresponding rhenium complexes, and the results indicated that there were differences between 99mTc-CO-MIBI and Re-CO-MIBI in preparation and hydrophobic characteristics.
The inter-transformations between [99mTc(CO)3(H2O)(MIBI)2]+, [99mTc(CO)3(MIBI)3]+, and [99mTc(CO)2(MIBI)4]+ were investigated. The biodistribution results showed that [99mTc(CO)3(MIBI)3]+ had the most favorable characteristics for cardiac imaging. The structure characterization on their corresponding rhenium complexes indicated that there were differences between 99mTc-CO-MIBI and Re-CO-MIBI in preparation and hydrophobic characteristics.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 693, Issue 10, 1 May 2008, Pages 1822–1828