کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1325142 977372 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, structure and biological activity of amide-functionalized titanocenyls: Improving their cytotoxic properties
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Synthesis, structure and biological activity of amide-functionalized titanocenyls: Improving their cytotoxic properties
چکیده انگلیسی

Nine amide-functionalized titanocenyls have been synthesized and characterized by spectroscopic and analytical methods and the solid state structure of Cp(CpCO-NH-C6H4-OCF3)TiCl2 was determined by single crystal X-ray diffraction. X-ray analysis of Cp(CpCO-NH-C6H4-OCF3)TiCl2 showed that titanium is in a pseudo tetrahedral geometry and contains a Ti–O(amide) coordination. In principle, Ti–O coordination should provide more hydrolytic stability to the corresponding titanocenyls than titanocene dichloride. The cytotoxic activities of these amide-functionalized titanocenyls on HT-29 colon cancer cell line were determined by MTT assay to elucidate structure-activity relationship. All complexes were more cytotoxic than titanocene dichloride and there is no correlation between the para substituents on the phenyl ring and their cytotoxicities.

Nine amide-functionalized titanocenyls have been synthesized, characterized and their cytotoxic properties on colon cancer cell line HT-29 investigated. All titanocenyl complexes were more cytotoxic than titanocene dichloride and there is no correlation between the para substituents on the phenyl ring and their cytotoxicities.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Organometallic Chemistry - Volume 694, Issue 26, 15 December 2009, Pages 4134–4139
نویسندگان
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