Synthesis and antibacterial activity of pyridylselenium compounds: Self-assembly of bis(3-bromo-2-pyridyl)diselenide via intermolecular secondary and π⋯π stacking interactions

• Pyridylseleniums and its hydrochloride salts have been synthesized.
• Antibacterial action studied by SEM/TEM and enzyme-profiling techniques.
• Bis(3-bromo-2-pyridyl)diselenide exhibits π⋯π stacking interactions.

Various pyridylseleniums and their hydrochloride salts have been synthesized and evaluated for their antibacterial activities. SEM, TEM and enzyme profiling techniques have been used to investigate the mode of action of these compounds as antibiotics. Single crystal X-ray study of bis(3-bromo-2-pyridyl)diselenide (6b) has also been reported. The molecule 6b displays π⋯π stacking and π⋯Br secondary interactions leading to a supramolecular self-assembly. A search on Cambridge Structural Database was undertaken to identify the π⋯π stacking interactions in various other bis(2-pyridyl)diselenides.

Pyridylseleniums have been evaluated for their antibacterial activities against five bacterial strains. SEM, TEM and the enzyme profiling have been used to investigate the mode of action of these compounds as antibiotics. Bis(3-bromo-2-pyridyl) diselenide exhibits short intermolecular secondary and π⋯π stacking interactions that lead to a self-assembled supramolecular architecture.Figure optionsDownload as PowerPoint slide