Synthesis of ferrocene derivatives functionalized with α-methylene-γ-butyrolactone rings

• Synthesis of ferrocene derivatives functionalized with α-methylene-γ-butyrolactone rings.
• α-Methylene-γ-butyrolactones are versatile structural units present in various important natural products.
• Reformatsky-type reaction applied in the synthesis of organometallic compounds.

This work reports the synthesis and characterization of new ferrocene derivatives functionalized with one or two α-methylene-γ-butyrolactone rings. These compounds were prepared via Reformatsky-type reaction between carbonyl ferrocene derivatives and ethyl 2-bromomethylacrylate in 33–85% yields.

This work reports the synthesis of new ferrocene derivatives functionalized with one or two α-methylene-γ-butyrolactone rings by reformatsky-type reaction.Figure optionsDownload as PowerPoint slide