کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1325741 | 977399 | 2008 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Enantioselective reductions of [m] ferrocenophanones Enantioselective reductions of [m] ferrocenophanones](/preview/png/1325741.png)
Enantioselective reductions of prochiral ferrocenophane ketones were investigated. Oxazaborolidine mediated reduction led to corresponding chiral alcohols generally in good yields and enantioselectivities up to 97% ee. Ruthenium-catalyzed transfer hydrogenation was rather unsuccessful in reducing cyclic ferrocene ketones. Proline-derived activator together with trichlorosilane also proved to be an effective method for some substrates (up to 99% ee). Pronounced tendency of α-ferrocenyl ketones toward reductive deoxygenation was studied by DFT computational methods.
Prochiral ferrocenophane ketones were enantioselectively reduced. Oxazaborolidine mediated reduction and proline-derived activator with trichlorosilane proved to efficient methods, with enantioselectivities up to 97% ee and 99% ee, respectively. Ruthenium-catalyzed transfer hydrogenation was rather unsuccessful in reducing cyclic ferrocene ketones.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 693, Issue 19, 15 September 2008, Pages 3131–3134