کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1326466 | 977432 | 2009 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Stereocontrolled synthesis of tertiary silanes via optically pure 1,3,2-oxazasilolidine derivatives Stereocontrolled synthesis of tertiary silanes via optically pure 1,3,2-oxazasilolidine derivatives](/preview/png/1326466.png)
Optically pure 1,3,2-oxazasilolidine derivatives were synthesized from a chiral 1,2-amino alcohol. These heterocyclic compounds containing a stereogenic silicon atom produced tertiary silanes with excellent optical purity through successive reactions with Grignard reagents and diisobutylaluminum hydride. Stereochemical course of the reactions of the oxazasilolidine at the chiral silicon atom was elucidated based on the absolute configurations of the products and the substrate which were determined by chiral HPLC and X-ray crystallographic analyses.
Optically pure 1,3,2-oxazasilolidine derivatives were synthesized from chiral 1,2-amino alcohols. The oxazasilolidine derivatives afforded tertiary silanes with excellent optical purity through successive reactions with Grignard reagents and DIBAL. Stereochemical course of the reactions was determined based on an X-ray crystallographic analysis.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 694, Issue 14, 15 June 2009, Pages 2171–2178