کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1326847 | 977447 | 2007 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: An amino acid bioconjugate of an organoplatinum tris(pyrazolyl)borate complex: Synthesis and structure of [p-(tBuO–Phe–CO)C6H4Tp]PtMe3 An amino acid bioconjugate of an organoplatinum tris(pyrazolyl)borate complex: Synthesis and structure of [p-(tBuO–Phe–CO)C6H4Tp]PtMe3](/preview/png/1326847.png)
The platinum trimethyl complex of a benzoic acid-functionalized hydrido-tris(pyrazolyl)borate (Tp) ligand [p-(HO2C)C6H4Tp]PtMe34 has been synthesized from the corresponding p-bromo complex [p-BrC6H4Tp]PtMe33. Compound 4 may be readily coupled to biomolecules such as amino acids as exemplified by coupling to l-phenylalanine-tert-butylester to provide [p-(tBuO–Phe–CO)C6H4Tp]PtMe35. Compound 5 has been structurally characterized in the solid state by X-ray diffraction. It constitutes the first example of a tris(pyrazolyl)borate bioconjugate.
A tetravalent organoplatinum complex of a benzoic acid-functionalized-Tp ligand p-(HO2C)C6H4TpPtMe3 has been synthesized and shown to undergo coupling to phenylalanine-tert-butylester to provide the first tris(pyrazolyl)borate bioconjugate [p-(tBuO–Phe–CO)C6H4Tp]PtMe3 which has been structurally characterized by X-ray diffraction.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 692, Issue 6, 15 February 2007, Pages 1310–1314