Pharmacokinetics and tissue distribution of the antileukaemic organoarsenicals arsthinol and melarsoprol in mice

A pharmacokinetics study of antileukaemic melarsoprol and arsthinol has been done. In the bone marrow, arsenic concentrations were very high, especially that of melarsoprol. The brain concentrations were high, although lower than in the bone marrow. This fact is in accordance with the antileukaemic activity and the brain toxicity of these organoarsenicals.