کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1327173 | 977465 | 2006 | 6 صفحه PDF | دانلود رایگان |

The synthesis of monomer, dimer, tricyclohexyl- and triphenyl-tin(IV) complexes with phthalimido-4-methyl pentanoic acid (PMPA) are described and characterized by FT IR, CHN analyzer, 1H, 13C 119Sn NMR and 119mSn Mössbauer spectroscopic techniques. In vitro ED50, anti-tumor (phytotoxic), anti-yeast, blood pressure and heart rate effect, and bactericidal, fungicidal as well as analgesic bioassays of complexes are also be carried out. The ligand (PMPA) shows excellent analgesic activity while the dimer exhibit strong biocidal and excellent anti-tumor behavior besides of tri-organotin(IV) complexes.
The phthalimido-4-methylpentanoic acid (PMPA) was synthesized and used as ligand for synthesis of bioactive monomer, dimer, tricyclohexyl- and triphenyl-tin(IV) complexes. The various spectroscopic techniques such as 1H-, 13C- 119Sn-NMR, FT IR, CHN analyzer, and 119mSn Mössbauer with literature evidences were employed to evaluate their geometry. They were screened out through in vitro ED50, anti-tumor (phytotoxic), anti-yeast, blood pressure and heart rate effect, and bactericidal, fungicidal as well as analgesic bioassays. The ligand (PMPA) was found to have excellent analgesic effect while the dimer exhibit strong biocidal and excellent anti-tumor behavior besides of tri-organotin(IV) complexes.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 691, Issue 8, 1 April 2006, Pages 1803–1808