کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1327190 | 977467 | 2007 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Catalysis in water: Synthesis of β-amino amides by Sc(III) promoted condensation of silylketene pyridylthioacetal and imines Catalysis in water: Synthesis of β-amino amides by Sc(III) promoted condensation of silylketene pyridylthioacetal and imines](/preview/png/1327190.png)
The scandium (III) catalysed condensation of silylketene thioacetals and pyridylthioacetals with imines in pure water was studied. The reaction of the phenylthioacetal derivatives brings always to β-aminoesters; the reaction of pyridylthioacetals leads to the stereoselective formation of β-lactams in organic solvents, while in the presence of a large amount of water affords β-amino amides in good yields. That represents a new, easy, one-pot catalytic synthesis in water of an interesting class of compounds, direct precursors of 1,3-diamino hydroxy compounds. The possibility of recovering and recycling the catalytic systems was also briefly investigated.
The scandium (III) catalysed condensation of silylketene thioacetals and pyridylthioacetals with imines in pure water affords amino amides in good yields. That represents a new, easy, one pot catalytic synthesis in water of an interesting class of compounds, direct precursors of 1,3-diamino hydroxy compounds.Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 692, Issue 26, 15 December 2007, Pages 5795–5798