کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1327472 977484 2005 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Allylic hydroxy phosphonates: versatile chiral building blocks
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی معدنی
پیش نمایش صفحه اول مقاله
Allylic hydroxy phosphonates: versatile chiral building blocks
چکیده انگلیسی

Allylic hydroxy phosphonates are converted into β and γ substituted amino phosphonates using a series of palladium-catalyzed reactions. The judicious selection of nitrogen nucleophile and palladium catalyst allow for excellent regio- and stereochemical control. Palladium(0)-catalyzed amine addition or tosyl carbamate rearrangement gives rise to the γ-substituted phosphonates, whereas, reaction of tosyl carbamates with palladium (II) and base gives oxazolidinones (β-substitution).

Allylic hydroxy phosphonates are converted into β and γ substituted amino phosphonates using a series of palladium-catalyzed reactions. The judicious selection of nitrogen nucleophile and palladium catalyst allow for excellent regio- and stereochemical control. Palladium(0)-catalyzed amine addition or tosyl carbamate rearrangement gives rise to the γ-substituted phosphonates, whereas, reaction of the tosyl carbamates with palladium (II) and base gives oxazolidinones (β-substitution).Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Organometallic Chemistry - Volume 690, Issue 10, 16 May 2005, Pages 2577–2592
نویسندگان
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