Gold(I)-catalyzed hydroarylation of allenes with indoles

Reaction of a monosubstituted, 1,3-disubstituted, or tetrasubstituted allene with various indoles catalyzed by a 1:1 mixture of a gold(I) N-heterocyclic carbene complex and AgOTf at room temperature leads to hydroarylation with formation of 3-allyl-indoles in modest to good yield.

Reaction of monosubstituted, 1,3-disubstituted, or tetrasubstituted allenes with an indole in the presence of a catalytic 1:1 mixture of a gold(I) N-heterocyclic carbene complex and AgOTf at room temperature leads to hydroarylation with formation of 3-allyl-1,2-dimethylindoles in modest to good yield.Figure optionsDownload as PowerPoint slide