کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1327915 | 977517 | 2005 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis, crystal structure and in vitro antitumor activity of di-n-butyltin 4′-(7-oxabicyclo [2,2,1]-5-heptane-2,3-dicarboximide) benzoates Synthesis, crystal structure and in vitro antitumor activity of di-n-butyltin 4′-(7-oxabicyclo [2,2,1]-5-heptane-2,3-dicarboximide) benzoates](/preview/png/1327915.png)
Dibutyltin(IV) oxide reacts with the cantharidin analogue, 4′-(7-oxabicyclo [2,2,1]-5-heptane-2,3-dicarboximide) benzoic acid, A, to give the complexes [(p-C8H8NO3–C6H4–COOBu2Sn)2O]2 (1) and (p-C8H8NO3–C6H4–COO)2SnBu2 (2) which had been characterized by IR and 1H, 13C, 119Sn NMR. Single X-ray crystal structure analysis has been determined for compound (1), which was analogue to most other [(RCOOBu2Sn)2O]2. The dimer features central of Bu4Sn2O2 unit with the two Bu2Sn groups being linked via bridging oxygen atom. Each tin atom adopts distorted trigonal bipyramidal structures via two carbons from a dibutyl moiety and three oxygen atoms from cantharidin derivative and bridging oxygen atom. In vitro tests show compounds 1 and 2 exhibit high cytotoxicity against P388 and HL-60.
The carboxylic acid reacts with the di-n-butyltin oxide yielding two different compounds depending on molar ratio acid/tin engaged in the reaction:bis[di-n-butyl(carboxylato)tin]oxide (compound 1) for a 1:1 ratio and di-n-butyltindi(carboxylate) (compound 2) for a 2:1 ratio. in vitro test shows that compound 1 and 2 exhibit high cytotoxicity against P388 and HL-60Figure optionsDownload as PowerPoint slide
Journal: Journal of Organometallic Chemistry - Volume 690, Issue 9, 29 April 2005, Pages 2186–2190