Palladium-catalyzed protection of alcohols and cleavage of triethylsilyl ethers

The versatility of the palladium (II) chloride/organosilane system has been tested in the transformation of alcohols to the corresponding silyl ethers and the subsequent deprotection of triethylsilyl ethers to the parent alcohols. The reaction takes place under mild conditions and affords high yields.

Silylethers are prepared in high yields by reaction of alcohols and different silanes in the presence of palladium (II) chloride catalyst at room temperature. Moreover, PdCl2/Et3SiH system was found very efficient for the deprotection of triethylsilyl ethers in ethanol.Figure optionsDownload as PowerPoint slide