Copper-catalyzed transformation of carbonyl-ene-nitrile compounds: Vinylation, imino ene reaction, and alkynylation of 2-aza-2,4-cyclopentadienone intermediates generated via Ritter-type hydration and dehydrative cyclization reactions

1H-pyrrolin-2(5H)-one derivatives are easily obtained from carbonyl-ene-nitrile compounds and alkenes or alkynes by copper(II)-catalyzed tandem sequence involving vinylation or allylation as well as Ritter-type hydration and dehydrative cyclization.

1H-pyrrolin-2(5H)-one derivatives are easily obtained from carbonyl-ene-nitrile compounds and alkenes or alkynes by copper(II)-catalyzed tandem sequence involving vinylation or allylation as well as Ritter-type hydration and dehydrative cyclization.Figure optionsDownload as PowerPoint slide