Stereoselective synthesis of vinyl sulfones by carbomagnesiation of acetylenic sulfone in the presence of CuCN

Carbomagnesiation of acetylenic sulfone in the presence of catalytic amount of CuCN gave α-sulfonyl vinyl magnesium reagent, which further reacted with aldehydes to afford polysubstituted vinyl sulfones in moderate to good yields.

Carbomagnesiation of acetylenic sulfone in the presence of catalytic amount of CuCN gave α-sulfonyl vinyl magnesium reagents, which further reacted with aldehydes to afford polysubstituted vinyl sulfones in moderate to good yields with good stereoselectivity.Figure optionsDownload as PowerPoint slide