کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1335330 | 1500263 | 2014 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Palladium(II) and platinum(II) oxamate complexes as potential anticancer agents: Structural characterization and cytotoxic activity Palladium(II) and platinum(II) oxamate complexes as potential anticancer agents: Structural characterization and cytotoxic activity](/preview/png/1335330.png)
The cytotoxic activity against human carcinogenic cells of five compounds, three of them containing palladium(II) and one containing platinum(II) was evaluated for the first time. These compounds were synthesized and characterized and present the formula K2(H2opba)·2H2O (1), K2[Pd(opba)]·2H2O (2), [Pd(NH3)4]Cl2·2H2O (3), [Pd(NH3)4][Pd(opba)] (4) and [Pt(H2opba)]·H2O (5), where opba = 1,2-phenylenebis(oxamate). Compounds 4 and 5 are novel and their synthesis and characterization are discussed in detail in this paper. The crystal structure of 4 was elucidated by single crystal X-ray diffraction and consists of discrete [Pd(NH3)4]2+cations interacting via hydrogen-bonds with [Pd(opba)]2− anions. Despite the fact that compound 1 has no significant effect on the growth of chronic myelogenous leukemia cells, its PdII and PtII complexes inhibit cellular growth in the following order of activity 2 ∼ 4 > 5. Compounds 2 and 4 are approximately 20 times more cytotoxic against leukemia cells than the free ligand.
The inhibition of leukemia cells growth by phenyloxamate platinum(II) and palladium(II) complexes were investigated suggesting their potential as cytotoxic agents.Figure optionsDownload as PowerPoint slide
Journal: Polyhedron - Volume 76, 7 July 2014, Pages 16–21