کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1338437 | 1500284 | 2013 | 10 صفحه PDF | دانلود رایگان |
1-(3-Aminopropyl)imidazole (Apim) reacts with salicylaldehyde and a selection of imidazole aldehydes and the resulting Schiff base ligands readily coordinate to Zn(II), Cu(II) and Ag(I) centres. X-ray crystal structures were obtained for two of the free ligands and also the Ag(I) complex of the Apim-salicylaldehyde ligand. Encouragingly, all of free ligands and most of their metal complexes are relatively non-toxic, in vivo, towards Galleria mellonella. Although the free ligands and the Cu(II) and Zn(II) complexes are inactive, in vitro, against a selection of microbial pathogens, most of the Ag(I) complexes exhibit moderate anti-bacterial activity and good anti-fungal activity.
Five ligand systems and fifteen metal (M = Cu, Ag or Zn) complexes were synthesised and characterised. X-ray crystal structures were obtained for two of the metal-free ligands and also the Ag(I) complex of the Apim-salicylaldehyde ligand. Although the metal-free ligands and the Cu(II) and Zn(II) complexes are inactive, in vitro, against a selection of microbial pathogens, most of the Ag(I) complexes exhibit moderate anti-bacterial activity and good anti-fungal activity.Figure optionsDownload as PowerPoint slide
Journal: Polyhedron - Volume 55, 17 May 2013, Pages 169–178