کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1338492 | 979668 | 2007 | 6 صفحه PDF | دانلود رایگان |
The chemical interactions of 1-methyl-3-hydroxy-4-pyridinecarboxylic acid (1M3H4P) and 1-methyl-4-hydroxy-3-pyridinecarboxylic acid (1M4H3P) with Fe(III) were investigated in aqueous 0.6 m (Na)Cl at 25 °C by means of potentiometric titrations and UV–Vis spectrophotometry. A large number of complexes were formed in solution with stoichiometry FeLxHy, x = 1, 2, 3 and y = 0, −1, −2. In view of a possible application to Fe(III) chelation therapy, the efficiencies of the ligands to chelate the metal ion were evaluated in vitro at physiological pH. 1M3H4P and 1M4H3P show a lower complexation efficiency with Fe(III) than that of other available chelators, but higher than that of their non-methylated analogs 3H4P and 4H3P.
The aqueous solution chemistry of Fe(III)/1-methyl-3-hydroxy-4-pyridinecarboxylic acid and Fe(III)/1-methyl-4-hydroxy-3-pyridinecarboxylic acid was studied by potentiometry and UV–Vis. Thermodynamic results were supplemented by chelation efficiency measurements. The two ligands show a lower efficiency with Fe(III) than that of available chelators, but higher than that of their non-methylated analogs 3-hydroxy-4-pyridinecarboxylic acid and 4-hydroxy-3-pyridinecarboxylic acid.Figure optionsDownload as PowerPoint slide
Journal: Polyhedron - Volume 26, Issue 13, 6 August 2007, Pages 3227–3232