کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
13412130 | 1841105 | 2019 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Can't or Won't? Immunometabolic Constraints on Dopaminergic Drive
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
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چکیده انگلیسی
Inflammatory cytokines have been shown to have a direct effect on mesolimbic dopamine (DA) that is associated with a reduced willingness to expend effort for reward. To date, however, the broader implications of this communication between inflammation and mesolimbic DA have yet to be explored. Here, we suggest that the metabolic demands of chronic low-grade inflammation induce a reduction of striatal DA that in turn leads to a steeper effort-discounting curve because of reduced perceived ability (can't) versus preference (won't) for reward. This theoretical framework can inform how the mesolimbic DA system responds to increased immunometabolic demands during chronic inflammation, ultimately contributing to motivational impairments in psychiatric and other medical disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Cognitive Sciences - Volume 23, Issue 5, May 2019, Pages 435-448
Journal: Trends in Cognitive Sciences - Volume 23, Issue 5, May 2019, Pages 435-448
نویسندگان
Michael T. Treadway, Jessica A. Cooper, Andrew H. Miller,