کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
13461641 | 1845222 | 2020 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A statistical mechanical model for drug release: Relations between release parameters and porosity
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
ریاضیات
فیزیک ریاضی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
A lattice gas model is proposed for investigating the release of drug molecules on devices with semi-permeable, porous membranes in two and three dimensions. The kinetic of this model was obtained through the analytical solution of the three-dimension diffusion equation for systems without membrane and with Monte Carlo simulations. Pharmaceutical data from drug release is usually adjusted to the Weibull function, exp[â(tâÏ)b], and the dependence of adjusted parameters b and Ï is usually associated, in the pharmaceutical literature, with physical mechanisms dominating the drug dynamics inside the capsule. The relation of parameters Ï and b with porosity λ are found to satisfy, a simple linear relation for between Ï and λâ1, which can be explained through simple physically based arguments, and a scaling relation between b and λ, with the scaling coefficient proportional to the system dimension.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 540, 15 February 2020, 123165
Journal: Physica A: Statistical Mechanics and its Applications - Volume 540, 15 February 2020, 123165
نویسندگان
Márcio Sampaio Gomes-Filho, Marco Aurélio Alves Barbosa, Fernando Albuquerque Oliveira,