کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
13461641 1845222 2020 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A statistical mechanical model for drug release: Relations between release parameters and porosity
موضوعات مرتبط
مهندسی و علوم پایه ریاضیات فیزیک ریاضی
پیش نمایش صفحه اول مقاله
A statistical mechanical model for drug release: Relations between release parameters and porosity
چکیده انگلیسی
A lattice gas model is proposed for investigating the release of drug molecules on devices with semi-permeable, porous membranes in two and three dimensions. The kinetic of this model was obtained through the analytical solution of the three-dimension diffusion equation for systems without membrane and with Monte Carlo simulations. Pharmaceutical data from drug release is usually adjusted to the Weibull function, exp[−(t∕τ)b], and the dependence of adjusted parameters b and τ is usually associated, in the pharmaceutical literature, with physical mechanisms dominating the drug dynamics inside the capsule. The relation of parameters τ and b with porosity λ are found to satisfy, a simple linear relation for between τ and λ−1, which can be explained through simple physically based arguments, and a scaling relation between b and λ, with the scaling coefficient proportional to the system dimension.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physica A: Statistical Mechanics and its Applications - Volume 540, 15 February 2020, 123165
نویسندگان
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