کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1355461 | 981012 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design, synthesis and biological evaluation of dinucleotide mRNA cap analog containing propargyl moiety
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The first example of the synthesis of new dinucleotide cap analog containing propargyl group such as m7,3′-O-propargylG[5′]ppp[5′]G is reported. The effect of propargyl cap analog with standard cap was evaluated with respect to their capping efficiency, in vitro T7 RNA polymerase transcription efficiency, and translation activity using cultured HeLa cells. It is noteworthy that propargyl cap analog outperforms standard cap by 3.1 fold in terms of translational properties. The propargyl cap analog forms a more stable complex with translation initiation factor eIF4E based on the molecular modeling studies.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 24, Issue 6, 15 March 2016, Pages 1204–1208
Journal: Bioorganic & Medicinal Chemistry - Volume 24, Issue 6, 15 March 2016, Pages 1204–1208
نویسندگان
Muthian Shanmugasundaram, Irudaya Charles, Anilkumar R. Kore,