کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1355689 | 981055 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ridaifen B, a tamoxifen derivative, directly binds to Grb10 interacting GYF protein 2
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Ridaifen B (RID-B) is a tamoxifen derivative that potently inhibits breast tumor growth. RID-B was reported to show anti-proliferating activity for a variety of estrogen receptor (ER)-positive human cancer cells. Interestingly, RID-B was also reported to possess higher potency than that of tamoxifen even for some ER-negative cells, suggesting an ER-independent mechanism of action. In this study, a T7 phage display screen and subsequent binding analyses have identified Grb10 interacting GYF protein 2 (GIGYF2) as a RID-B-binding protein. Using a cell-based assay, the Akt phosphorylation level mediated by GIGYF2 was found to have decreased in the presence of RID-B.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 21, Issue 1, 1 January 2013, Pages 311–320
Journal: Bioorganic & Medicinal Chemistry - Volume 21, Issue 1, 1 January 2013, Pages 311–320
نویسندگان
Senko Tsukuda, Tomoe Kusayanagi, Eri Umeda, Chihiro Watanabe, Yu-ta Tosaki, Shinji Kamisuki, Toshifumi Takeuchi, Yoichi Takakusagi, Isamu Shiina, Fumio Sugawara,