Synthesis and an angiolytic role of novel piperazine–benzothiazole analogues on neovascularization, a chief tumoral parameter in neoplastic development

• A series of piperazine-benzothiazole analogues 6a–j were synthesized.
• Synthesized compounds were characterized by spectral studies.
• Compounds 6a–j were evaluated for in vitro anti-proliferative activity.
• Compound 6c showed extensive antiproliferative activity.
• Compound 6c shows increased tumor suppression through inhibition of angiogenesis.

A novel series of benzoic acid N′-[2-(4-benzothiazol-2-yl-piperazin-1-yl)-acetyl]-hydrazides 6a–j were synthesized and characterized by IR, 1H, 13C NMR, elemental and mass spectral analyses. The in-vitro cytotoxicity and cell viability assay of the synthesized compounds 6a–j were evaluated against Dalton’s lymphoma ascites (DLA) cells. Our results showed that compound 6c with a bromo group on phenyl ring has showed promising antiproliferative efficacy. Further investigation of compound 6c on in-vivo treatment model depicts the increased tumor suppression through inhibition of angiogenesis.

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