کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1355743 | 981059 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The binding site of zinc and indium metal to amino acid derivatized squarate complexes - Implications in inhibitor and mediator designs
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Three novel metal squaric acid-peptide complexes, SQI-SQIII were prepared by addition of indium triflate or zinc chloride to the previously reported compounds [1], 3-(hydroxymethylamino)-4-(l-isoleucine methyl ester)-3-cyclobutene-1,2-dione (squarate 1), and 3-(hydroxymethylamino)-2-(l-isoleucine methyl ester)-4-thioxo-2-cyclobuten-1-one (squarate 2). The structures of SQI-SQIII were elucidated using NMR analysis. The electrochemical applications of two of these metal-squaric acid systems (SQI and SQII) were also investigated. Incorporation of SQII as a mediator, in the previously optimized Pt/p(HEMA)/p(pyrrole)/GOx electrode using the ionic liquid [bmim][BF4] as the solvent medium, produced a biosensor with enhanced properties, namely a sensitivity of 175.9Â mA/M d-glucose, working potential of +200Â mV, large linear range (0-12Â mM) and a detection limit of 1Â ÃÂ 10â6Â M.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic Chemistry - Volume 38, Issue 5, October 2010, Pages 234-241
Journal: Bioorganic Chemistry - Volume 38, Issue 5, October 2010, Pages 234-241
نویسندگان
Natasha Ramroop-Singh, Dyer Narinesingh, Gurdial Singh, Christopher T. Seto, Anthony B. Comeau,