کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1355816 981065 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ortho-Carbaborane derivatives of indomethacin as cyclooxygenase (COX)-2 selective inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
ortho-Carbaborane derivatives of indomethacin as cyclooxygenase (COX)-2 selective inhibitors
چکیده انگلیسی

A series of novel indomethacin analogues with carbaboranes as three-dimensional substitutes for the chlorophenyl ring have been prepared. Their cyclooxygenase (COX) inhibition and enzyme selectivity has been tested and compared to the corresponding adamantyl analogues. Surprisingly, only the ortho-carbaborane derivatives were active compounds. Preliminary biological studies gave an interesting insight into the validity of employing carbaboranes as pharmacophores.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 20, Issue 15, 1 August 2012, Pages 4830–4837
نویسندگان
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