Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN

• Structure elucidation of a novel Homoisoflavonoid that was identified as Scillapersicone.
• The structure of Scillapersicone was established by single crystal X-ray analysis.
• The low energy gap of Scillapersicone can caused cytotoxicity on cancerous cell lines.

In this study isolation and structural elucidation of a homoisoflavonoid, 3-(3′,4′-dihydroxybenzyl)-8-hydroxy-5,7-dimethoxychroman-4-one (Scillapersicone 1), is reported from Scilla persica HAUSSKN. The structure was solved by a single crystal X-ray analysis. The unit cell parameters are a = 11.7676 (2) Å, b = 20.1174 (4) Å, c = 7.8645 (9) Å, β = 93.544 (2)°, V = 1858.23 (7) Å3, monoclinic space group P21/c and four symmetry equivalent molecules in an unit cell. The structure was consistent with the UV, IR, 1D and 2D NMR, HRFAB-MS data. The optimized molecular geometry agrees closely that obtained from the single crystal X-ray crystallography. Furthermore, cytotoxicity of this compound was evaluated by MTT assay on AGS and WEHI-164 cancerous cell lines.

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