Design, synthesis and biological evaluation of novel thiosemicarbazide analogues as potent anticonvulsant agents

• A series of novel thiosemicarbazide derivatives are synthesised.
• Amongst the synthesised compounds, some of compounds showed good anticonvulsant activity.
• Amongst synthesised compounds, compound 5e and 5g has been identified as lead anticonvulsant agents.

Novel thiosemicarbazide derivatives were synthesised and evaluated for their anticonvulsant activity and neurotoxicity. Anticonvulsant activity was done for grand mal and petit mal types of epilepsies by maximal electroshock (MES) and pentylenetetrazol (PTZ) induced convulsions methods respectively. Rotarod test was done to determine neurotoxicity. Amongst synthesised compounds, N-(4-bromophenyl)2-[(2-phenylhydrazinyl) carbonothioyl] hydrazinecarbothioamide (5e) is a broad-spectrum anticonvulsant agent since it was active in both (MES) and (PTZ) induced seizure models with no neurotoxicity and N,N-(bis(chlorophenyl)hydrazine-1,2-dicarbothoamide (5g) acts as a selective agent for grand mal epilepsy.

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