Synthesis of 2-deoxy-hexopyranosyl derivatives of uridine as donor substrate analogues for glycosyltransferases

A series of 2-deoxy-hexopyranosyl derivatives of uridine have been synthesized as analogues of UDP-sugar. These compounds were tested as inhibitors against bovine β-1,4-galactosyltransferase I in fluorescent assays and showed no significant inhibition.

A series of UDP-sugar analogues were synthesized and tested as inhibitors against bovine β-1,4-galactosyltransferase I in fluorescent assays.Figure optionsDownload as PowerPoint slide