کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1356191 | 981096 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cytotoxic and anti-inflammatory cembranoids from the Vietnamese soft coral Lobophytum laevigatum Cytotoxic and anti-inflammatory cembranoids from the Vietnamese soft coral Lobophytum laevigatum](/preview/png/1356191.png)
Four new cembranoids, namely laevigatol A–D (1–4), and six known metabolites (5–10), were isolated from the Vietnamese soft coral Lobophytum laevigatum. The structures of these compounds were elucidated by extensive spectroscopic analyses, and the absolute stereochemistry of 1 was determined using the modified Mosher’s method. Compounds 5, and 7–10 exhibited cytotoxic activity against selected human cancer cell lines. Compounds 1, 2, 8, and 9 showed dose-dependent inhibitory effects on the TNFα-induced NF-κB transcriptional activity in Hep-G2 cells. Moreover, compounds 1, 2, 8, and 9 significantly inhibited the induction of COX-2 and iNOS mRNA dose-dependently, indicating that these compounds attenuated the synthesis of these transcripts at the transcriptional level.
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Journal: Bioorganic & Medicinal Chemistry - Volume 19, Issue 8, 15 April 2011, Pages 2625–2632