Novel amidino substituted 2-phenylbenzothiazoles: Synthesis, antitumor evaluation in vitro and acute toxicity testing in vivo

The series of new nitro-amidino, amino-amidino and diamidino-substituted 2-phenylbenzothiazoles were prepared. All compounds except diamidino-substituted 2-phenylbenzothiazole 9a show exceptionally prominent tumor cell-growth inhibitory activity.