کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1356418 981116 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel 4,4′-diether-2,2′-bipyridine cisplatin analogues are more effective than cisplatin at inducing apoptosis in cancer cell lines
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Novel 4,4′-diether-2,2′-bipyridine cisplatin analogues are more effective than cisplatin at inducing apoptosis in cancer cell lines
چکیده انگلیسی

The synthesis and characterization of dichloro(4,4′-bis[methoxy]-2,2′-bipyridine)platinum (1) and dichloro(4,4′-bis[3-methoxy-n-propyl]-2,2′-bipyridine)platinum (2) are described. As analogues to CDDP, these 4,4′-disubstituted 2,2′-bipyridine complexes exhibit decreased EC50 values of 10–100 times in cancer cell lines of the lung, prostate, and melanoma with several combinations of complex and cell line less than 10 μM. Flow cytometry data indicate ‘blocks’ of MDA-MD-435 cycle by 1 (G2/M) and 2 (S). Observed cell survival trends in the presence of 1, 2 under ionizing radiation mimic those of CDDP. Preliminary structure activity relationships are discussed for the 4,4′-substitutions made on the bipyridine ring.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry - Volume 18, Issue 3, 1 February 2010, Pages 1163–1170
نویسندگان
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